Slide background
Slide background




IARC Monographs Volume 128: Acrolein, Crotonaldehyde and Arecoline

ID 15019 | | Visite: 2105 | Documenti Chemicals EntiPermalink: https://www.certifico.com/id/15019

IARC Monographs Volume 128

IARC Monographs Volume 128

IARC Monographs on the Identification of Carcinogenic Hazards to Humans Volume 128: Acrolein, Crotonaldehyde and Arecoline

This volume of the IARC Monographs provides evaluations of the carcinogenicity of three chemicals: acrolein, crotonaldehyde, and arecoline.

Acrolein is a High Production Volume chemical used to manufacture numerous chemical products, and as a herbicide in recirculating water systems. Found in emissions from combustion of fuels, wood, and plastics, and in ambient air pollution and electronic cigarette vapour, acrolein is also generated in kitchens during high-temperature roasting and deep-fat frying. Firefighters are exposed occupationally. Crotonaldehyde is a High Production Volume chemical that is widely used for synthesizing chemical agents used in the pharmaceutical, rubber, chemical, and leather industries, as well as in food production and agriculture. Crotonaldehyde is also formed during combustion of vehicle fuels and wood, and in thermal treatment of food, and is also found in cooking fires, ambient air pollution, electronic cigarette vapour, and some foods and heated cooking oils. Occupational exposures to crotonaldehyde occur among firefighters, coke-oven workers, and workers in aldehyde manufacture, garages, and toll booths. Tobacco smoke is a major source of crotonaldehyde and acrolein exposure in the general population. Both acrolein and crotonaldehyde are also formed endogenously.

Arecoline is the primary active ingredient of the areca nut, which is carcinogenic to humans (Group 1). At least 10% of the global population, primarily in south-eastern Asia, chews areca nut for its mild psychoactive effects. Arecoline has been used medicinally as an anthelmintic and is still applied in the form of areca-nut preparations in traditional Chinese and Ayurveda medicines.

An IARC Monographs Working Group reviewed evidence from cancer bioassays in experimental animals and mechanistic studies to assess the carcinogenic hazard to humans of exposure to these agents and concluded that:

- Acrolein is probably carcinogenic to humans (Group 2A)
- Crotonaldehyde and arecoline are possibly carcinogenic to humans (Group 2B).

Collegati

Descrizione Livello Dimensione Downloads
Allegato riservato IARC Monographs Volume 128.pdf
 
8524 kB 8

Tags: Chemicals Abbonati Chemicals Agente chimico

Articoli correlati

Ultimi archiviati Chemicals

Piano nazionale di controllo ufficiale degli additivi e aromi alimentari 2023
Mag 02, 2025 475

Piano nazionale di controllo ufficiale degli additivi e aromi alimentari - 2023

Piano nazionale di controllo ufficiale degli additivi e aromi alimentari - Attività 2023 ID 23919 | 02.05.2025 / In allegato La presente relazione contiene i risultati analitici dell’attività svolta nel 2023 in adempimento a quanto previsto dal “Piano nazionale riguardante il controllo ufficiale… Leggi tutto
ECHA Annual report 2024
Apr 19, 2025 829

ECHA Annual report 2024

ECHA Annual report 2024 ID 23848 | 19.04.2025 / Attached ECHA’s achievements in 2024 reflect a strong commitment to our strategic goals and priorities, as well as our vision of chemical safety through science, collaboration and knowledge. We continued to progress and implement our existing legal… Leggi tutto
Piano nazionale di controllo ufficiale degli additivi e aromi alimentari 2025 2027
Apr 17, 2025 913

Piano nazionale di controllo ufficiale degli additivi e aromi alimentari 2025-2027

Piano nazionale di controllo ufficiale degli additivi e aromi alimentari 2025-2027 ID 23839 | 17.04.2025 / In allegato Piano nazionale di controllo ufficiale degli additivi e aromi alimentari come materia prima e negli alimenti comprese le sostanze aromatizzanti di affumicatura anni 2025-2027 Il… Leggi tutto
Apr 08, 2025 848

Decreto 27 marzo 2025 | Suppl. 11.7 Farmacopea europea 11ª ed.

Decreto 27 marzo 2025 | Suppl. 11.7 Farmacopea europea 11ª ed. ID 23772 | 08.04.2025 Decreto 27 marzo 2025 Entrata in vigore dei testi, nelle lingue inglese e francese, pubblicati nel supplemento 11.7 della 11ª edizione della Farmacopea europea. (GU n.82 del 08.04.2025) _________ Art. 1. 1. I testi… Leggi tutto

Più letti Chemicals

Notifica HACCP
Apr 05, 2022 99547

Notifica ai fini registrazione Regolamento CE n. 852/2004

Notifica ai fini della registrazione (Reg. CE n. 852/2004) - Ex notifica sanitaria alimentare ID 7901 | 06.03.2019 / Modello notifica allegato [panel]Regolamento (CE) 852/2004...Articolo 6 Controlli ufficiali, registrazione e riconoscimento 1. Gli operatori del settore alimentare collaborano con le… Leggi tutto