Slide background
Slide background




IARC Monographs Volume 128: Acrolein, Crotonaldehyde and Arecoline

ID 15019 | | Visite: 2238 | Documenti Chemicals EntiPermalink: https://www.certifico.com/id/15019

IARC Monographs Volume 128

IARC Monographs Volume 128

IARC Monographs on the Identification of Carcinogenic Hazards to Humans Volume 128: Acrolein, Crotonaldehyde and Arecoline

This volume of the IARC Monographs provides evaluations of the carcinogenicity of three chemicals: acrolein, crotonaldehyde, and arecoline.

Acrolein is a High Production Volume chemical used to manufacture numerous chemical products, and as a herbicide in recirculating water systems. Found in emissions from combustion of fuels, wood, and plastics, and in ambient air pollution and electronic cigarette vapour, acrolein is also generated in kitchens during high-temperature roasting and deep-fat frying. Firefighters are exposed occupationally. Crotonaldehyde is a High Production Volume chemical that is widely used for synthesizing chemical agents used in the pharmaceutical, rubber, chemical, and leather industries, as well as in food production and agriculture. Crotonaldehyde is also formed during combustion of vehicle fuels and wood, and in thermal treatment of food, and is also found in cooking fires, ambient air pollution, electronic cigarette vapour, and some foods and heated cooking oils. Occupational exposures to crotonaldehyde occur among firefighters, coke-oven workers, and workers in aldehyde manufacture, garages, and toll booths. Tobacco smoke is a major source of crotonaldehyde and acrolein exposure in the general population. Both acrolein and crotonaldehyde are also formed endogenously.

Arecoline is the primary active ingredient of the areca nut, which is carcinogenic to humans (Group 1). At least 10% of the global population, primarily in south-eastern Asia, chews areca nut for its mild psychoactive effects. Arecoline has been used medicinally as an anthelmintic and is still applied in the form of areca-nut preparations in traditional Chinese and Ayurveda medicines.

An IARC Monographs Working Group reviewed evidence from cancer bioassays in experimental animals and mechanistic studies to assess the carcinogenic hazard to humans of exposure to these agents and concluded that:

- Acrolein is probably carcinogenic to humans (Group 2A)
- Crotonaldehyde and arecoline are possibly carcinogenic to humans (Group 2B).

Collegati

Descrizione Livello Dimensione Downloads
Allegato riservato IARC Monographs Volume 128.pdf
 
8524 kB 8

Tags: Chemicals Abbonati Chemicals Agente chimico

Articoli correlati

Ultimi archiviati Chemicals

Lug 03, 2025 550

Regolamento (Euratom) 2021/765

Regolamento (Euratom) 2021/765 ID 24219 | 03.07.2025 Regolamento (Euratom) 2021/765 del Consiglio del 10 maggio 2021 che istituisce il programma di ricerca e formazione della Comunità europea dell'energia atomica per il periodo 2021-2025 che integra il programma quadro di ricerca e innovazione… Leggi tutto
Lug 03, 2025 560

Regolamento (Euratom) 2025/1304

 Regolamento (Euratom) 2025/1304 ID 24218 | 03.07.2025 Regolamento (Euratom) 2025/1304 del Consiglio, del 23 giugno 2025, che istituisce il programma di ricerca e formazione della Comunità europea dell’energia atomica per il periodo 2026-2027 che integra il programma quadro di ricerca e innovazione… Leggi tutto
ECHA compendium of analytical methods
Giu 27, 2025 787

ECHA compendium of analytical methods for enforcing REACH restrictions - Ed. 3.0 2025

ECHA compendium of analytical methods for enforcing REACH restrictions - Ed. 3.0 2025 ID 24178 | 27.06.2025 / Attached ECHA has updated its compendium of analytical methods to help authorities to enforce and companies to comply with REACH restrictions. The compendium consists of a collection of… Leggi tutto
ECHA 2025   Key Areas of Regulatory Challenge
Giu 11, 2025 920

ECHA 2025 - Key Areas of Regulatory Challenge

ECHA 2025 - Key Areas of Regulatory Challenge ID 24098 | 11.06.2025 / Attached The report introduces new topics to reflect ECHA’s growing responsibilities. It also covers emerging topics in waste and recycling that aim to support circularity and enhance Europe’s industrial competitiveness. For… Leggi tutto

Più letti Chemicals

Notifica HACCP
Apr 05, 2022 103686

Notifica ai fini registrazione Regolamento CE n. 852/2004

Notifica ai fini della registrazione (Reg. CE n. 852/2004) - Ex notifica sanitaria alimentare ID 7901 | 06.03.2019 / Modello notifica allegato [panel]Regolamento (CE) 852/2004...Articolo 6 Controlli ufficiali, registrazione e riconoscimento 1. Gli operatori del settore alimentare collaborano con le… Leggi tutto