Handbook on the Toxicology of Metals / Ed. 3 2009
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| 27 Novembre 2024 | ||
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Handbook on the Toxicology of Metals / Ed. 3 2009 ID 20706 | 03.11.2023 / In allegato The Handbook on the Toxicology of Metals is a comprehensive review dealing with the effects of metallic elements and their compounds on biological systems. Special emphasis has been laid on the toxic effects in humans, although toxic effects in animals and biological systems in vitro are also discussed whenever relevant. As a basis for a better understanding of the potential for adverse effects on human health, information is also given on sources, transport, and transformation of metals in the environment and on certain aspects of the ecological effects of metals. The first edition of the handbook appeared in 1979, and was followed by a second edition in 1986. The work rapidly fulfi lled the aims of the editors and became a standard reference work for physicians, toxicologists, and engineers in the fi elds of environmental and occupational health. There has been a long interval between the 2nd edition and the present one, but the aims of this third edition are basically the same as those of the previous editions, i. e., to provide easy access to basic toxicological data and also give more in-depth treatment of some information, including a general introduction to the toxicology and risk assessment of metals and their compounds. As with the previous editions, writing the 3rd edition of this book has been a part of the activities within the Scientifi c Committee on the Toxicology of Metals under the International Commission on Occupational Health, and the editors are happy that the work to make a third edition has been given a high priority among members. In some cases, we have been honored to include authors from outside of this committee. The chapter authors have, as far as possible, been the same as those who wrote the second edition, but in many cases, we were happy to introduce new colleagues. Since the publication of the 2nd edition, a wealth of data has appeared, and several of the chapters dealing with specific metals have been completely rewritten; others have undergone a comprehensive updating. In order to not expand the present book and make it much larger than the second edition, which was published in two volumes, some of the general chapters have been merged and shortened, and the present book is published in one volume in a larger format. For the interested reader who searches more detailed information on specific topics, each chapter contains a large number of relevant references also to recent reviews whenever these are available. Index Ed. 3 2009 CHAPTER 1 - Introduction—General Considerations and International Perspectives The development of modern devices in society demand new chapters which refl ect the present concerns of the use of new materials, such as semiconductors in electronic devices, metallic nanotechnology devices, and platinum- and palladium-based catalytic converters. The increasing use of biomarkers in occupational and environmental health has made it necessary to add a new chapter on biological monitoring and biomarkers. Immunotoxicology is an expanding field, and considerable achievements have been made in recent years. A chapter on “immunotoxicology of metals” has therefore been included. Immunological and genetic findings provide, in some cases, good explanations for the differences in susceptibility to development of disease from exposure to metals. Principles for prevention of the toxic effects of metals and risk assessment are important chapters, somewhat expanded, and a new chapter on a related topic “Essential Metals: Assessing Risks from Deficiency and Toxicity” brings up-to-date knowledge into this 3rd edition. Before the manuscript of this 3rd edition could be finalized, our co-editor and friend Professor Lars Friberg died. He was the main editor of the two first editions of this handbook, and his ideas constituted the basis for the present edition. His stringent analytical views were invaluable, and his expertise and knowledge are greatly missed. We will also remember him as a loyal, generous, and warm friend, and hope that this book will be a lasting tribute to his memory. The editors acknowledge each contributor to this book for their devotion and enthusiasm and for having prioritized the work to make the 3rd edition of Handbook on Toxicology of Metals available to the reader. Editors: Gunnar F. Nordberg, Bruce A. Fowler, Monica Nordberg
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