Guidelines for user of the aprotic solvents

Guidelines for user of the aprotic solvents / ECHA March 2026

ID 25907 | 01.04.2026 / Attached

How to comply with REACH Restriction 71, 76, 80 and 81; guideline for users of the aprotic solvents NMP, DMF, DMAC, and NEP

This document aims to support users of 1-methyl-2-pyrrolidone (NMP), N,Ndimethylformamide (DMF), N,N dimethylacetamide (DMAC), 1-ethylpyrrolidin-2-one (NEP), or with mixtures containing those substances (C ≥ 0.3 %), to comply with the related restriction requirements under the REACH Regulation.

Moreover, this guideline may help enforcement authorities to understand what is expected to comply with the restrictions and evaluate the compliance at a site. NMP, DMF, DMAC, and NEP are aprotic solvents and have a harmonised classification as toxic for reproduction (reproductive toxicant category 1B). In Europe, those aprotic solvents are subject to REACH Annex XVII restrictions: Entry 71 for NMP, Entry 76 for DMF, Entry 80 for DMAC and Entry 81 for NEP. If you use one of those aprotic solvents in your workplace, you need to protect anyone who could be exposed to it. 

This guideline is intended to help you understand what you need to do to comply with the provisions of those restrictions but also against the background of your existing occupational safety and health (OSH) obligations.

This guideline follows the 2019 NMP restriction guideline, but now also includes DMF, DMAC, and NEP REACH restrictions from 2021 (DMF) and 2025 (NEP and DMAC). 
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ECHA March 2026

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