Type of information that can be found via eChemPortal:

Risk Assessment and Industrial Chemical.

General information:

Canada’s Existing Substances Assessment Repository (CESAR) contains risk and other regulatory assessment reports on existing chemicals which include individual substances, groups or classes of chemicals, or effluents or wastes that are produced or imported in Canada or released into the Canadian environment. Under Canada’s Canadian Environmental Protection Act (CEPA), these assessments are aimed at determining whether or not these substances present or may present a risk to the environment and/or human health in a Canadian context. The assessments thus address common environmental and human health endpoints under four main themes: 1) the substance identity 2) the entry, fate and exposure characterization, 3) the effects characterization and 4) the risk characterization. A weight-of-evidence approach and precaution are applied throughout the assessment process. The risk assessment program under CEPA is conducted in collaboration by both Environment Canada and Health Canada. Assessments found within this repository are generally from two major initiatives from Canada: the Chemicals Management Plan, including the Challenge, as well as the Priority Substances List (PSL) Assessment Program. For more details about these two initiatives, please visit: https://www.canada.ca/en/health-canada/services/chemical-substances.html.

The risk and other regulatory assessments of existing chemicals in CESAR are useful to a diversity of audiences, including hazard assessors (in governments, industry or health organisations), educators, health and medical professionals, and the general public.

Type of information:

Hazard assessments, risk assessments, exposure assessments, combined exposure assessments, National GHS classifications, industrial chemicals, new industrial chemicals, pesticides, biocides, portal, regulation information.

General information:

The Joint Substance Data Pool of the German Federal Government and Federal States (GSBL) is now called ChemInfo.

The Information System on Chemicals of the German Federal Government and the German Federal States (ChemInfo), formerly known as the Joint Substance Data Pool of the German Federal Government and Federal States (GSBL) is a continuously maintained, uniform collection of validated information on chemical substances. The mission of the cooperation is to provide public authorities (e.g., police, fire brigades, governmental authorities, etc.) and the general public with reliable, topical chemicals information in support of all activities to prevent and avert danger and to protect humans and the environment.

ChemInfo comprises a wide range of features of chemical substances. Records contain information on physical and chemical properties, on ecotoxicological and toxicological parameters and on environmental fate. They provide descriptions of environmental hazards, health dangers, fire and other technical hazards and give information on relevant chemicals-related legislation.

The information contained is partly elaborated directly for the ChemInfo database by utilising the cooperation’s own resources and partly obtained from numerous external suppliers (BAuA, BAM, RESY, BIG, GDL, ETOX, RIGOLETTO, et al.). The current version contains information on some 51,000 pure substances, 26,000 component substances (mixtures and preparations) and substance-related information on 226 relevant German and European legislation.

Type of information that can be found via eChemPortal:

Hazard assessments.

General information:

The database includes a variety of studies where chemicals are grouped together for a risk assessment that is usually limited to one or a few human health or environmental endpoint(s). The risk assessment may be very succinct (e.g. including threshold of toxicological concerns only for the hazard part of the assessment) or fully detailed (e.g. including robust study summaries). The database does not contain the studies itself but will point users to links where the studies are available. These links may be from regulatory agencies or other intergovernmental. The database should be useful for the dissemination of studies of combined exposures to multiple chemicals as this is an emerging regulatory issue.

The list of studies and chemicals included can be found on this page.

US EPA Center for Computational Toxicology and Exposure 

“Type” of information in your data source

The EPA CompTox Chemicals Dashboard contains publicly available chemical property data (both experimental and predicted), toxicity data, including hazard, risk, and exposure assessments, use information and in vitro bioactivity data.

• Hazard assessments 
• Risk assessments
• Exposure assessments 
• Use patterns 
• Industrial chemicals 
• New industrial chemicals 
• Pesticides
• Biocides
• Portal 

General information:

The CompTox Chemicals Dashboard is EPA's integrated hub providing access to publicly available chemical property and environmental fate and transport data, hazard and exposure information, risk management, chemical usage and in vitro bioactivity data associated with the ToxCast and Tox21 screening programs. The web-based application can be used to find publicly available data about potential chemical risks to human health and the environment. The dashboard aggregates data from 100s of public sources for over 1,200,000 environmental chemicals and is searchable by CASRN, chemical names and synonyms, molecular formula and mass, and by chemical structure.

The Dashboard compiles data (both quantitative and qualitative) from a large number of sources including EPA databases, online data sources and web-based collections, state and other national sources, and from academic groups.

For more information, see https://www.epa.gov/chemical-research/comptox-chemicals-dashboard and https://www.epa.gov/chemical-research/comptox-chemicals-dashboard-resource-hub and read the publication (https://jcheminf.biomedcentral.com/articles/10.1186/s13321-017-0247-6).

Type of information that can be found via eChemPortal:

• Biocides
• Active substances used in biocidal products
• Risk assessments
• Hazard assessments
• Exposure assessments

General information:

The ECHA website provides electronic public access to information on biocidal active substances manufactured or imported in Europe. The information originates from the assessment reports, submitted by the Member State Competent Authorities in the framework of the Biocidal Products Regulation. Currently, information on about 360 biocidal active substances are available via the ECHA website.

It should be noted that the dissemination of information concerning biocidal active substances is made according to the combinations of the active-substance with the product-types in which it can be used. The product types under the BPR relate to the type of use the substance is envisaged to cover when part of a biocidal product.

For more information see: https://echa.europa.eu/regulations/biocidal-products-regulation/product-types

The information ECHA makes available on its website includes:

• The IUPAC name/EC number/ CAS number of the substance
• Approval status
• Whether the substance is considered a candidate for substitution
• The relevant product-type
• Link to related authorised products that make use of the active substance
• Link to active substance factsheet (by clicking on the ‘eye’)

Depending on the progress of the assessment and subsequent approval or non-approval, the following documents may be available in the substance factsheet (example of active substance factsheet available here):

• MSCA Assessment Reports – With information on
• Identity, Physico-chemical Properties and Methods of analysis,
• Intended Uses and Efficacy,
• Classification and Labelling,
• Human Health Risk assessment and Environmental Risk assessment
• See example of assessment report here
• Study summaries
• Biocidal Products Committee opinions on the approval of the active substance, resulting from the peer review of the Assessment Reports
• See example of BPC opinion here
• Links to European Commission Implementing Regulations

Type of information:

Classification and labelling information according to the CLP Regulation (EC) No 1272/2008 – implementing the GHS in the EU.

General information:

The ECHA C&L inventory is an EU public C&L inventory that provides electronic public access to classification and labelling information on chemical substances placed on the market in the European Union.

The database contains classification and labelling information on notified and registered substances received from manufacturers and importers in the framework of the REACH and CLP Regulations ((EC) No 1907/2006 and No 1272/2008) in their C&L notifications or registration dossiers. This information is not reviewed by ECHA and can only be searchable via the “Substance Search” functionality of eChemPortal.

In addition, the ECHA C&L inventory includes the list of the harmonised classifications according to the CLP Regulation (Table 3.1 of Annex VI to the CLP Regulation). Certain situations require that the classification of a substance is harmonised and made obligatory at Community level to ensure an adequate risk management throughout the European Community. The substances with harmonised classifications are searchable via the “GHS Search” functionality of eChemPortal.

The number of entries in the database is increasing over time as companies submit new dossiers and the CLP Regulation (Table 3.1 of Annex VI to the CLP Regulation) is amended on a regular basis. As such, the data in the inventory itself are refreshed frequently.

The ECHA C&L inventory is maintained by the European Chemicals Agency (ECHA).

Type of information that can be found via eChemPortal:

Hazard properties, national GHS classification and labelling (CLP Regulation),information on how to use the chemicals safely.

General information:

The ECHA website provides electronic public access to information on chemical substances manufactured or imported into Europe. The information originates from the registration dossiers submitted by companies to the European Chemicals Agency (ECHA) in the framework of the REACH Regulation. Currently, about 25,000 substances are available via the ECHA website.

Type of information that can be found via eChemPortal:

Links to all EFSA’s publications dealing with risk assessments of chemicals in food and feed since its creation in 2002. These include all Scientific Opinions, statements and EFSA’s conclusion on pesticides performed by its Scientific Panels, the Scientific Committee and units.

• Hazard Assessments
• Exposure assessments
• Risk assessments
• Pesticides
• Vitamins and minerals
• Novel foods
• Dietetic products
• Contaminants in the food and feed chain
• Feed additives
• Food additives
• Food contact materials
• Processing aids
• -Nutrient Sources

General information

The report collection provides access to risk assessments from EFSA’s Scientific Committee, Scientific panels and units:

• The Scientific Committee (SC) of EFSA providing scientific advice in the area of new and harmonised approaches for risk assessment of food and feed.
• The Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) replaced in 2008 by the Panel on Food Additives and Nutrient Sources Added to Food (ANS) dealing with food additives, nutrient sources and other substances deliberately added to food, excluding flavourings and enzymes;  the Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF) dealing food contact materials, enzymes, flavourings and processing aids, and processes such as recycling.
• The Panel on Contaminants in the Food Chain (CONTAM) dealing with contaminants in the food chain.
• The Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) dealing with additives and products or substances used in animal feed.
• The Panel on Dietetic Products, Nutrition and Allergies (NDA) dealing with nutrition, dietetic products, including vitamins, minerals and novel food ingredients.
• EFSA’S Pesticide Risk assessment Unit (PRAS) dealing with pesticides in the food chain.

The report collection provides data for hazard identification, hazard characterisation, exposure assessment and risk characterisation:

• Human health endpoints for regulated products (AFC, ANS, CEF, CONTAM, FEEDAP, NDA panels, SC and pesticide unit) and for contaminants (CONTAM) including toxicological endpoints and health based guidance (e.g. Acceptable Daily Intake, Acute Reference Dose, Acceptable Operator Exposure Level, Tolerable Daily Intake) and  margin of exposures for contaminants that are genotoxic and carcinogenic.
• Animal health endpoints (Target species and non-target species) for feed additives, pesticides and contaminants (FEEDAP, CONTAM, PRAS) and ecotoxicological endpoints (FEEDAP, PRAS).

The added value of EFSA’s chemical hazards database is significant since it provides direct searchable access to all EFSA publications in the field of human health, animal health and environmental risk assessment for thousands of substances. Relevant audiences include 1. risk assessors and toxicologists from national and international governmental bodies, industry, health organisations, 2. researchers in academia, educators, health and medical professionals, human toxicologists and epidemiologists, nutritionists, veterinarians and veterinary toxicologists, ecotoxicologists, 3. general public.

More detailed descriptions are available of EFSA’s website: http://www.efsa.europa.eu/en/aboutefsa/efsawhat.htm 

Type of information that can be found via eChemPortal:

Property data sets of industrial chemicals, pesticides and biocides.

General information:

EnviChem is a factual database containing test results data on ca. 3000 substances. EnviChem contains data related to the effects, fate and behaviour of chemicals in the environment. The most extensive part of the report is the toxicity data (LC/EC/IC50, LOEC, NOEC etc.) of substances to aquatic organisms. There are also data on physico-chemical properties, degradation, metabolism, bioaccumulation and the effects of the substance to terrestrial species eg. plants and mammals.

The content of EnviChem database is useful to environmental researchers, authorities, hazard assessors and companies dealing with chemicals. Correct interpretation of the core data requires some experience of environmental hazard assessment and chemistry.

“Type” of information in your data source

Toxicological Information, Hazard assessments, Risk assessments, Drinking water intake, Pesticides, Portal

General information:

EPA derived the Human health benchmarks for pesticides by applying the health effects data from pesticide registrations to the typical methods used for developing drinking water health advisories.  EPA developed the human health benchmarks for pesticides to enable states, water systems and the public to better determine whether the detection of a pesticide in drinking water or source waters for drinking water may indicate a potential health risk.

Type of information that can be found via eChemPortal:

Ecotoxicological Information, Hazard assessments, Risk assessments, Pesticides, Portal.

General information:

The aquatic life benchmarks (for freshwater species) provided are based on toxicity values reviewed by the U.S. Environmental Protection Agency (EPA) and used in the Agency's most recent risk assessments developed as part of the decision-making process for pesticide registration. Each Aquatic Life Benchmark is based on the most sensitive, scientifically acceptable toxicity endpoint available to EPA for a given taxon (for example, freshwater fish) of all scientifically acceptable toxicity data available to EPA.  Acute and chronic benchmarks are developed for freshwater fish and invertebrates and for aquatic vascular and nonvascular plants.  Each of the chemical benchmarks is linked to the EPA ecological risk assessment chapter from which they were used.  These aquatic benchmarks are extracted from the most recent publically available OPP risk assessment for the pesticide and are based on the most sensitive aquatic toxicity data of the distribution for each taxa. Benchmarks, developed for baseline risk assessments, are estimates of the concentrations below which pesticides are not expected to harm aquatic life. Comparing a measured concentration of a pesticide in water with an aquatic life benchmark can be helpful in interpreting monitoring data, and to identify and prioritize sites and pesticides that may require further investigation. For more information,  please visit: https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/aquatic-life-benchmarks-and-ecological-risk#benchmarks

General information:

The ETOX database allows access to effects information from aquatic and terrestrial ecotoxicology. Furthermore, ETOX contains information on various national and international environmental quality guidelines, targets, standards, criteria, and limit values. In focus are substances, which are relevant for assessment of surface water pollution to trigger the development of environmental quality standards according to Water Framework Directive 60/2000/EC. Currently, the ETOX database contains approximately 55,000 entries on effects to aquatic organisms, approximately 5,000 entries on effects to terrestrial organisms, as well as approximately 4,500 entries on various national and international environmental quality guidelines, targets, standards, criteria, and limit values for the protection of water and soil. A link list with information providers for the assessment of substances, the search of ecotoxicity data, and environmental quality targets is provided.

GHS Classification Results by the Japanese Government  

General information:

The USEPA High Production Volume Information System (HPVIS) provides access to select health and environmental effects information on chemicals that are produced or imported into the US in quantities of 1 million pounds or more each year. Information in this database is submitted through EPA’s High Production Volume (HPV) Challenge Program. Sponsor (company/consortium) information, test plans, robust summaries, and EPA and public comments are available in the HPVIS. In addition, HPVIS provides access to available EPA Hazard Characterizations and Risk-Based Prioritization Documents for selected chemicals. As of August, 2008, HPVIS contains information on 1102 chemical substances reported in 366 submissions, representing 244 single chemical and 122 chemical category submissions. Some chemicals are reported in multiple submissions.

General information:

HSDB® is a toxicology file focusing on the toxicology and environmental fate of potentially hazardous chemicals. The file contains over 5,000 records with data on human health effects, animal toxicity studies, standards and regulations, chemical/physical properties, pharmacology, emergency medical treatment, safety and handling, environmental exposure, and more.

HSDB is a valuable resource to professionals and the general public due to its comprehensiveness. HSDB allows users to access various types of data in one file.

HSDB is now included in PubChem. This NIH NLM page provides guidance about using PubChem to find the HSDB content: https://www.nlm.nih.gov/toxnet/index.html

Type of information:

The CCID contains the GHS classifications, brief physical property data and a summary of the data upon which the classification is based for industrial chemicals and some pesticide actives. 

General information:

The CCID is a database of chemicals classified by the New Zealand Environmental Protection Authority (EPA) in accordance with the EPA Hazardous Substances (Classification) Notice 2020. This Notice, issued under the New Zealand Hazardous Substances and New Organisms Act (HSNO), incorporates the UN Globally Harmonised System for Classification and Labelling of Chemicals (GHS) revised edition 7 by reference, with the addition of classifications for terrestrial ecotoxicity (applied only to agrichemicals).

The majority of chemicals were classified by the EPA upon transition into the HSNO Act during 2001-2006. The classification system was updated to GHS in 2021 and the existing classifications migrated across without review of the data.

Type of information:

Hazards assessments, GHS classifications, Industrial chemicals, Pesticides

General information:

The International Chemical Safety Cards (ICSCs) provide essential safety and health information on approximately 1,700 chemicals in a concise format. The focus is on information relevant to safe use of chemicals in the workplace. This includes short descriptions of health hazards, fire and explosion hazards, physical and chemical properties and dangers, and recommendations for spillage disposal, storage and packaging. Classification according to GHS is provided for an increasing proportion of the collection. The information is available in 14 languages (with further languages in development): English, Spanish, Persian, French, Finnish, Hebrew, Hungarian, Italian, Japanese, Korean, Polish, Portuguese, Russian, Chinese.
The ICSCs are a joint activity of the International Labour Organization and the World Health Organization –www.ilo.org/icsc.

Type of information:

• Risk assessments
• Hazard assessments
• Exposure assessments
• GHS classifications
• Pesticides
• Biocides
• Industrial chemicals

General information:

IGS provides public access to a variety of information on chemical and microbiological substances mostly in German. The software interface is switchable between English and German. The focus is on regulatory information reflecting German and European, as well as Swiss, US and selected other legislation and assessments. Beside this, information on substance data and emergencvy procedures is available. The database is designed for the use by officials and employers, but also for the general public.

Type of information that can be found via eChemPortal:

Hazard assessments.

General information: 

INCHEM provides a single consolidated collection of chemical-safety information from intergovernmental organizations; and rapid electronic access to information on chemicals used throughout the world and which may occur as contaminants in the environment and food. The collection consists of over 8000 documents in full-text format which are available free-of-charge.

Type of information that can be found via eChemPortal:

Property data sets (test data), Hazard assessments, Industrial chemicals, Pesticides, Biocides

General information:

In this tools, INERIS highlights the data on chemical substances in these studies and research. PSC provides data on chemicals in the following areas: identification, regulations, physico-chemical properties, behavior (fate in environment, degradation, accumulation...), ecotoxicity (acute and chronic), toxicity (accidental and chronic), technico-economic data.

In this tools, INERIS highlights the data on chemical substances in these studies and research. PSC provides data on chemicals in the following areas: identification, regulations, physico-chemical properties, behavior (fate in environment, degradation, accumulation...), ecotoxicity (acute and chronic), toxicity (accidental and chronic), technico-economic data.

These data are copyright-free and the search is done through the name/CAS number of substances and/or on regulatory text/national work program.

The PSC is the property of INERIS.

Type of information that can be found via eChemPortal:

Exposure assessments, Combined exposure assessments, Human Biomonitoring Data, Environmental Monitoring Data, Food and Feed Monitoring Data and Product and Indoor Air Monitoring Data.

General information:

IPCheM is a single access point for locating and accessing chemical monitoring data across all media in the European Union. Operated by the European Commission in collaboration with some European Union Agencies, it is developed to address the lack of information on the chemical exposure and burden on the humans and the environment, recognised as the major gap in the knowledge base for chemical policies in several policy documents in the past 15 years. IPCheM is not a database but a decentralised system providing remote access to existing chemical monitoring data and information systems: while providers maintain the structure of their databases, the provision of data therein is harmonised in order to be accessible, retrievable and comparable through a unique interface. This creates greater visibility and promotes a wider use of valuable chemical monitoring data, thus increasing the knowledge base for sound risk assessment, management and communication. Combining information and chemical data from different sources on a variety of environmental media, consumer products and food, and ultimately from human beings themselves, provides the basis for better understanding the effects of exposure to chemical mixtures. Further information can be found at:

General information

J-CHECK is a database developed to provide the information regarding "Act on the Evaluation of Chemical Substances and Regulation of Their Manufacture, etc. " (CSCL) by the authorities of the law, Ministry of Health, Labour and Welfare, Ministry of Economy, Trade and Industry, and Ministry of the Environment.

J-CHECK provides information regarding CSCL, such as the list of CSCL, chemical safety information obtained in the existing chemicals survey program, Japan Challenge Program, etc.

Hazard information

• Biodegradation
• Bioaccumulation
• Partition coefficient
• Alga growth inhibition test
• Daphnia Acute Immobilization test
• Daphnia Reproduction test
• Fish Acute toxicity test
• Fish prolonged toxicity test
• Fish early life stage toxicity test
• Others 

Type of information that can be found via eChemPortal:

Hazard assessments and industrial chemicals.

General information:

The Japan Existing Chemical Data Base makes available the toxicity test reports from Japan's existing chemicals safety programme. Each report consists of the nomenclature of the chemical, abstracts and summarized data from the studies in English. Individual study reports are available in Japanese.

Type of information that can be found via eChemPortal:

Hazard assessments, Exposure and use information, Schedules of assessments and industrial chemicals.

General information: 

The status of all HPV chemicals within the process of investigation in the  OECD HPV Chemicals Programme  is recorded in the OECD Existing Chemicals Database. It contains the list of all OECD HPV chemicals together with any annotations on each chemical which has been provided by Member countries to the Secretariat. Each chemical is identified as to exactly which stage it is at in the assessment process, and for those chemicals which have been assessed, a link to internet pages where completed assessments can be downloaded is provided.

Type of information:

Industrial chemicals, New industrial chemicals, Pesticides, Use patterns

The fact cards provide basic information on groups of PFAS substances including: (1) chemical identities, synthesis and inherent properties such as bioaccumulation and transformation, (2) historical and ongoing industrial practices and commercial uses of some major commercial products, (3) regulatory status, (4) examples of reported occurrences in the environment and humans, and (5) major knowledge gaps in terms of previous sections.

General information:

The fact cards aim to provide non-expert stakeholders a quick initial glance into these groups of PFASs with some basic information on: (1) chemical identities, synthesis and inherent properties such as bioaccumulation and transformation, (2) historical and ongoing industrial practices and commercial uses of some major commercial products, (3) regulatory status, (4) examples of reported occurrences in the environment and humans, and (5) major knowledge gaps in terms of previous sections. The fact cards also provide references where interested readers may find additional information. Fact cards on 15 groups of more than 100 PFAS substances including references to more than 240 names and synonyms are available.

The Fact Cards were developed in the context of the OECD/UNEP Global PFC Group which was established to respond to the Resolution II/5 adopted at the second session of the UN International Conference on Chemicals Management (ICCM 2) in 2009, which calls upon intergovernmental organizations, governments and other stakeholders to “consider the development, facilitation and promotion in an open, transparent and inclusive manner of national and international stewardship programmes and regulatory approaches to reduce emissions and the content of relevant perfluorinated chemicals of concern in products and to work toward global elimination, where appropriate and technically feasible”. For more information on the work of the Global PFC Group please consult the OECD PFAS portal: https://www.oecd.org/chemicalsafety/portal-perfluorinated-chemicals/

OECD SIDS IUCLID data is available in eChemPortal and can be found through the property search but the links to the database are temporarily unavailable

Type of information that can be found via eChemPortal:

Property data sets and industrial chemicals.

General information:

The IUCLID software is the preferred tool for entering data and developing a SIDS Dossier for High Production Volume Chemicals in the OECD HPV Chemicals Programme.  For those SIDS Dossiers which were elaborated with the IUCLID software, the Dossiers can be viewed on this site. The IUCLID export files for these SIDS Dossiers also can be downloaded and then imported into a local IUCLID installation.

Type of information in your data source

Total volume (sum of production and import minus export) for each year since 2000 for more than 30.000 substances and the volumes in each industry and each product category for each of the participating countries. Exposure assessments, Use patterns, Industrial chemicals, Volumes.

General information:

The Nordic Council of Ministers through the Nordic Chemicals Group is behind the SPIN initiative.

SPIN, Substances in Preparations In the Nordic countries contains information on more than 30.000 chemical substances from each of the Nordic product registers. SPIN is designed to provide the public with as much data as possible from the registers without disclosing confidential business information. The national product registers in Denmark, Finland, Norway and Sweden are unique. They are valuable sources of data concerning the downstream uses of chemical substances in products on the national markets. New functionality and design give professional users fast and easy access to chemical information. SPIN contains information for every year from 2000 onwards and is annually updated.

“Type” of information in your data source

The ECOTOXicology Knowledgebase (ECOTOX) is an online source for locating single chemical toxicity data from the peer-reviewed literature, for aquatic and terrestrial species.

Because ECOTOX contains test data from thousands of research publications, it will contain information regarding many of the chemicals in this list.  New toxicity data are added to the ECOTOX website every quarter, including data for additional chemicals and biological species.

General information:

The ECOTOX Knowledgebase is a comprehensive, publicly available application providing chemical environmental toxicity data on aquatic life, terrestrial plants and wildlife. Data are curated from the peer-reviewed scientific literature and grey literature after an exhaustive search protocol.

The ECOTOXicology Knowledgebase (ECOTOX) is a source for locating single chemical toxicity data for aquatic life, terrestrial plants and wildlife. ECOTOX was created and is maintained by the U.S.EPA.  ECOTOX integrates three previously independent databases into a unique system which includes toxicity data derived predominately from the peer-reviewed literature, for aquatic life, terrestrial plants, and terrestrial wildlife, respectively.  It also includes data from independently compiled data sets (e.g. EPA’s Fathead Minnow database, the USGS Acute Toxicity database, and international datasets).   All data are compiled from comprehensive search and review of open and grey literature.  Criteria for inclusion into the Knowledgebase is based on many factors (e.g,, must be verifiable CASRN, ecologically relevant species, report a control or endpoint, etc.).  Criteria is listed on our homepage Help section under “Data Limitations” (https://cfpub.epa.gov/ecotox/help.cfm)

• Used for every Environmental Protection Agency’s Office of Water Ambient Water Quality Criteria for Aquatic Life since 1985.
• Used for every Ecological Risk Assessment for Environmental Protection Agency’s Office of Pesticides for chemical registration and re-registration.
• Used by Environmental Protection Agency’s Office of Land and Emergency Managements’ Superfund and RCRA programs, HQ, Regions and States for site assessments and emergency response.
• Provides ecological hazard data for the prioritization and assessment of chemicals for TSCA/Lautenberg Act.

Type of information that can be found via eChemPortal:

Hazard assessments, risk assessments and property data sets.

General information:

Risk Evaluation Reports contain full risk assessment for the environment, including human health hazard assessment, based on all available valid data.

In addition, two reports look at flame retardant chemicals and alkylphenols with a view to prioritisation for environmental risk assessment. The former focuses on environmental properties and hazards of known and possible chemicals used as flame retardants, while the latter addresses environmental properties and hazards of possible replacement chemicals for nonylphenol.

Type of information that can be found via eChemPortal:

EPA’s IRIS website provides over 550 chemical specific webpages which include links to: Executive Summary/IRIS Summary reports; toxicological reviews (for assessments produced since 1997); other supporting documents; and includes tables with reference concentrations (RfCs) and reference doses (RfDs) values that can be derived from a NOAEL, LOAEL, or benchmark dose, with uncertainty factors generally applied to reflect limitations of the data used; and cancer descriptors that characterize a chemical’s carcinogenic potential and the conditions under which the chemical may pose a carcinogenic risk to humans; and oral cancer slope factors (OSF) and inhalation unit risks (IUR). The IRIS website also releases a quarterly Program Outlook (which is a table of assessments in development), a calendar of public science meetings; a quick A-to-Z searchable table of chemicals for quick sorting; and a more advanced search of the underlying database. See https://www.epa.gov/iris

General information:

EPA’s Integrated Risk Information System (IRIS) is a human health assessment program that evaluates quantitative and qualitative risk information on effects that may result from exposure to environmental contaminants. IRIS was initially developed for EPA staff in response to a growing demand for consistent information on substances for use in risk assessments, decision-making, and regulatory activities. The information in IRIS is intended for those without extensive training in toxicology, but with some knowledge of health sciences. Please see: https://www.epa.gov/iris/basic-information-about-integrated-risk-information-system for more information.

General information:

The Substance Registry Services (SRS) is the Environmental Protection Agency's (EPA) central system for information about regulated and monitored substances. It is the portal for discovering chemical information at EPA. The system provides a common basis for identification of chemicals, biological organisms, and other substances listed in EPA regulations and data systems, as well as substances of interest from other sources, such as publications.

For each chemical, the SRS provides basic core metadata, including Chemical Abstract Service (CAS) names and CAS numbers. SRS identifies an EPA standardized name for each chemical (e.g., “Toluene” for the chemical with CAS name “Benzene, methyl-”). SRS also includes the molecular weights, molecular formulae, former CAS numbers and descriptions (when available).

A second section of each SRS substance record provides statutory or list information on each chemical. For each US environmental statute, the SRS identifies the list of chemicals named on that statute and the synonym used. For each US EPA data system, the SRS identifies the list of chemicals in that data system and the synonym used. The SRS also has chemical lists for external organizations, such as lists maintained by other US federal agencies or lists maintained by international organizations.

A third section provides links, if available, from the SRS to other sites for additional information. These links might be to other substance registry systems, such as those managed by other federal agencies or international organizations, or to fact sheets about the chemical.